This study examined the effect of ICT, as a tool for enhancement of transaction management for SME businesses in Nigeria. A survey was conducted in Delta South Senatorial district of Delta State, Nigeria. A total number of Seventy-three (73) SMEs operators were randomly selected as the sample size. Descriptive statistics which include frequency counts and percentages were used to describe the sample and to assess ICT use. Regression analysis was used to assess the relationship and influence of technology, organization, and environment characteristics on use of ICT. The findings showed that ICT use has a significant positive relationship with the constructs of the Technology, Organization, and Environment (TOE) Framework. The TOE Constructs also have joint influence on the use of ICT by the SMEs. Discussion of findings, summary, and conclusion along with research contribution were also presented in this study. It concluded that technology, organization, and environment features are indeed relevant to the study of ICT Use among the SMEs. Therefore, it was recommended that stakeholders must take seriously in planning the activities of SMEs and the corresponding related research work.