Therapeutic communication is one of the important keys in providing patient care in hospital. Nurses who have the skills to communicate, not only will be easily establish a relationship of trust with the patients, but also preventing illegal businesses, as well as increase patient satisfaction in hospitals. This study aimed to analyze the relationship between therapeutic communication nurse with patient satisfaction inpatien in hospitals massenrempulu enrekang. The research is an analytic observational study with cross sectional design. The population in this study were all patients in the inpatient Hospitals Massenrempuluinstallations in 2017 with the number of patients as many as 6575 people. Sampling technique in this research used accidental sampling method with a total sample of 226 patients. Datawas collected by questionnaire interviews. Data were analyzed using chi square test and multiple logistic regression. The results showed that the majority of respondents age 40-49 years (29.2%), female (58.8%), junior high school education (36.3%) and working as farmers (35.4%). The analysis showed that there was a relationship of openness (p = 0,040) empathy (p = 0,036) supportive attitude (p = 0,036) positive attitude (p = 0,001) and equality (p = 0,000) and patient satisfaction. Multivariate analysis with multiple logistic regression showed that the most dominant variable associated with patient satisfaction was equality (Exp B = 33.041). As conclusion that the therapeutic nurse communication is related to patient satisfaction.