This article under review summarizes clinical and animal model studies that prove the potential of ingredients of saffron including safranal, crocetin and crocins extracts and their admixtures in treating of burn wound because of treating of burns still a receive attention in contemporary medicine, notably in developing nations that cannot supply costly and progressive medicines.Reviews presented in databases such as Google Scholar,Scopus,Pub-Med,Web of Science and Science Direct, published in English in 2008–2022,were considered.According to medical trials which described, it was shown that saffran extracts have notable effectiveness in treating of burn wounds, including reducing inflammation and speeding up the healing process than the conventional treatment used hitherto. This current review emphasis on the aspect of the main active comounds of saffron, on healing burn and the mechanisms investigated by researchers in treating. Researches on animal pattern indications that saffran preparation may have potential beneficial in the treatment burn wounds.According to antibacterial activity,mechanism of action, low toxicity and mild cost, saffran extracts can compete with conventional treatment.