Background: Clean and Healthy Living Behavior is behavior or a group of behaviors carried out based on will or awareness or learning outcomes that make a person and their family able to help themselves in the field of health and play an active role in realizing public health. Objective: to find out the determinants of implementing clean and healthy living behavior in the school setting at the Beurata Health Science College, Banda Aceh. Research method: Descriptive quantitative research with a cross sectional design with a total of 288 students obtained from total sampling based on inclusion and exclusion criteria. To collect research data on the variables of knowledge, attitudes, facilities, regulations, the role of lecturers, sanctions, a questionnaire was used. Data analysis includes univariate and bivariate using chii square. Results: The results of the univariate test showed that 189 respondents or 75.5% of students adopted clean and healthy living behavior, while 225 respondents or 90.5% of students had good knowledge about clean and healthy living behavior.The results of bivariate research showed that there was a relationship between knowledge and clean and healthy living behavior,markp valueP=0.000 and OR = 9.561.Conclusion:There needs to be a semester evaluation and a technical policy regarding the monitoring mechanism for clean and healthy living behavior among students at the Sihat Beurata Campus, Banda Aceh.