Azari Mehrdad Mohammad Ali. Periodontoprotective action of oral gel "Biotrit-Denta" in rats with sugar diabetes, received orthodontic treatment. Journal of Education, Health and Sport. 2018;8(8):1186-1192. eISNN 2391-8306. DOI http://dx.doi.org/10.5281/zenodo.1451740 http://ojs.ukw.edu.pl/index.php/johs/article/view/6164 The journal has had 7 points in Ministry of Science and Higher Education parametric evaluation. Part b item 1223 (26/01/2017). 1223 Journal of Education, Health and Sport eISSN 2391-8306 7 © The Author(s) 2018; This article is published with open access at Licensee Open Journal Systems of Kazimierz Wielki University in Bydgoszcz, Poland Open Access. This article is distributed under the terms of the Creative Commons Attribution Noncommercial License which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author (s) and source are credited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial license (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. This is an open access article licensed under the terms of the Creative Commons Attribution Non commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted, non commercial use, distribution and reproduction in any medium, provided the work is properly cited. The authors declare that there is no conflict of interests regarding the publication of this paper. Received: 02.08.2018. Revised: 14.08.2018. Accepted: 31.08.2018. UDK 616.31:616.37:616.179:379:008 PERIODONTOPROTECTIVE ACTION OF ORAL GEL "BIOTRIT-DENTA" IN RATS WITH SUGAR DIABETES, RECEIVED ORTHODONTIC TREATMENT Azari Mehrdad Mohammad Ali Odessa National Medical University flavan.ua@gmail.com Abstract Background. Significant changes in diabetes mellitus are observed in the oral cavity, which can affect by treatment measures. The purpose of this study was to determine the therapeutic effect of oral phytogel "Biotrit-Denta" on periodontal tissues of rats with experimental diabetes mellitus and received orthodontic treatment. Methods. Type 1 diabetes mellitus (DM1) was reproduced by alloxan. From 12-th day of the experiment rats were fixed in the month with orthodontic springs. One group of rats from the first day of the experiment received daily oral application gel "Biotrit-Denta". The duration of the experiments was 35 days. In the gum the level of inflammation markers (elastase, MDA), activity of urease, lysozyme, catalase were determined. The bone tissue of the alveolar process, the activity of alcoline (AlF) and acidic (AcF) phosphatases, the content of calcium and protein were determined. Results. Diabetes mellitus causes in periodontis of rats the development of inflammation, dysbiosis, decrease in immunity, antioxidant defense and the mineralizing activity of bone tissue. The orthodontic operation was no effect on the periodontal parameters that were changed in diabetes. Oral applications of gel "Biotrit-Denta" eliminated the phenomens of inflammation, dysbiosis and normalized the mineralising activity of bone tissue. Conclusion. Oral applications of gel "Biotrit-Denta" have periodontoprotective effect. Keywords: diabetes mellitus, paradontium, dysbiosis, inflammation, oral gel "Biotrit-Denta".