This repository contains data accompanying the pub "Structure-based protein clustering sometimes, but not always, provides insight into protein function" (doi: https://doi.org/10.57844/arcadia-a757-3651). In the pub, we use the deoxycytidine kinase family to evaluate the results of a tool designed for structure-based clustering. We utilized data from the literature and data that we obtained for five enzymes (found in the table below). There are three folders containing ProteinCartography data, enzyme activity analysis data, and purification data. The ProtienCartography data contains all of the data produced by running ProteinCartography, including the maps, clustering information, and all of the structures used in the analysis. The enzyme activity analysis data contains enzyme activity data that we obtained in the lab, as well as data obtained from the review "Non-viral deoxyribonucleoside kinases - diversity and practical use" (doi: https://doi.org/10.1016/j.jgg.2015.01.003). The purification data folder contains chromatograms, gels, and western blots from the purification of the following enzymes. UniProt ID Annotation Organism A0A4Y1QVV5 P-loop containing nucleoside triphosphate hydrolases superfamily protein (pd-dNK) Prunus dulcis (almond) A0A3P6ASY1 Deoxynucleoside kinase domain-containing protein (bc-dNK) Brassica campestris (field mustard) A0A2A5BCG8 Deoxynucleoside kinase domain-containing protein (rb-dNK) Unidentified Rickettsiales bacterium A0A7J5YK87 Deoxynucleoside kinase domain-containing protein (dm-dCK) Dissostichus mawsoni (Antarctic toothfish) P27707 Deoxynucleoside kinase Homo sapiens (human)