The effectiveness of social entrepreneurship depends on the ability of social enterprises to be sustainable. Therefore, this article attempts to identify the factors of effective applicability of social enterprise in terms of their sustainability. A social enterprise canbe fi nancially sustainable depending on factors of its effective applicability. This analysis is based on three case studies of social enterprises, namely Benetech, APOPO and Conserve. The findings of this article suggest that the burden imposed on social enterprises should be limited as their viability depends largely on the implementation of appropriate social policies. Social enterprises may be eliminated under excessive load, whilst under-loading may lead to the idle capacity meaning such enterprises are not efficient. The author defines five factors for increasing the effective applicability of social enterprises: state support for social enterprises; support provided to social enterprises by private creditors and sponsors; formation of the public opinion in favor of social entrepreneurship; design and marketing strategy of social enterprises' goods; unification of the efforts of the socially oriented state, social entrepreneurs and business realizing the futility and meaninglessness of maximizing the profit. The author proposes the measures of state support as a factor of strengthening the effective applicability of social enterprises, as well as the mechanism of subsidizing social enterprises by the state.