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DuneCopasi: A multi-compartment reaction-diffusion simulator for systems biology

Authors: Ospina De Los Ríos, Santiago; Bastian, Peter; Keegan, Liam; Sahle, Sven; Vermoortele, Dylan; Wehling, Lilija;

DuneCopasi: A multi-compartment reaction-diffusion simulator for systems biology

Abstract

DuneCopasi is a C++ library designed to simulate how chemical reactions and diffusion processes occur in space, which is crucial for understanding many biological systems. It allows users to model these processes in both simple and complex environments, using grids that represent one, two, or three dimensions. Optimized for modern computers, DuneCopasi can be used as a standalone command-line application, accessed through tools like Docker or a web-based terminal, as a C++ library, or integrated into a graphical interface. One such interface is the Spatial Model Editor (SME), which helps users create and manipulate biological reaction models. The project was initiated to provide the numerical foundation for a spatial modelling tool for biochemical reaction networks, complementing the COmplex PAthway SImulator (COPASI) software. This development resulted from a collaboration between the COPASI team and the Distributed and Unified Numerics Environment (DUNE) team.

This minor release with some small fixes and improvements from v2.0.1. Noteworthy are Many improvements to the online documentation, mostly a result of the peer review from the JOSS journal. Add experimental support numerical jacobians !204 and moving domains !205. Fixed wrong CMake configuration of higher order polynomial degrees !236. Fixed memory leak on the UMFPack solver !235. Fixed a upstream a performance bug where many memory allocations were done during the assembly of multi-domain problems, this was fixed in dune-grid. Assembly is now significantly faster. To see more details, check out the CHANGELOG file and the git-diff.

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average