These data present antibiotic resistance and antibiotic consumption trends in Europe over two decades. The data on the antimicrobial resistance rates are released by the European Surveillance System - TESSy, provided by Finland, Sweden, Belgium, Germany, Greece, Ireland, Italy, Luxembourg, Netherlands, Norway, Portugal, United Kingdom, Austria, Bulgaria, Czech Republic, Denmark, Estonia, Spain, Malta, Slovenia, France, Croatia, Hungary, Poland, Slovakia, Romania, Cyprus, Latvia, Lithuania and released by the European Centre for Disease Prevention and Control (ECDC). The AMR data cover the years 1998-2019. Fields in summary_AMC_byclass.csv: class: ATC code of antibiotic class Country: country Year: year Sector: Community or Hospital Antimicrobial.Type: mode of consumption DDD: defined daily dose per 1000 inhabitant combC: combination of factors for data manipulation purpose Antibiotic_class: same as class Fields in summary_AMR_filtered.csv: Year: year Country: country Pathogen: bacterial species Antibiotic: antibiotic resistance tested patientType: INPAT for inpatient N_S: number of sensitive strains test: combination of factors for data manipulation purpose N_tested: number of strains tested N: total number of strains p: fraction resistant or intermediate ci_span: width of the binomial 95% confidence interval p_min: 2.5% confidence interval p_max: 97.5% confidence interval Antibiotic_long: long name of the antibiotic Antibiotic_class: antibiotic class Pathogen_long: long name of the bacterial species combR: combination of factors for data manipulation purpose N_I_R: number of intermediate and resistant strains