The current study intended to produce a formulation for the anti-inflammatory and analgesic activities of Punicagranatum peel waste. Nonsteroidal anti-inflammatory medicines (NSAIDs) are associated with excessive side effects and adverse drug reactions. Constant usage of NSAIDs causes gastrointestinal discomfort and other negative effects on body organs such as the liver and kidneys. Punicagranatum peel extract has previously been shown to have anti-inflammatory and analgesic effects in many animal conditions. Pomegranate peels are typically a waste product from many pomegranate processing enterprises. These peelscontain polyphenols, flavonoids, and β-sitosterol, which help with inflammation. Inflammation is associated with discomfort, redness, and swelling. Flavonoids exhibit antioxidant action and indirectly reduce inflammatory indicators such as tumor necrosis factor alpha. Punicagranatum peels have analgesic properties and can help control discomfort. The ointment formulation of Punicagranatum peel performs well in all evaluation test parameters, including general appearance, consistency, pH, spreadability, extrudability, diffusion study, non-irritancy test, and stability study.