Cardiovascular diseases comprise the most prevalent serious disorders in the developed nations. Cardiotoxicity occurs during therapy with several drugs and may be the dose limiting factor in the treatment. In similar to Doxorubicin (antitumor) has been found to cause severe cardiac damage. Clinical and experimental investigations suggested that increased oxidative stress associated with an impaired antioxidant defence status initiates a cascade of reactions responsible for Drugs induced cardio toxicity. The interest to undertake this investigation is due to Argemone mexicana could be a potential source of natural antioxidant, that could have greater importance as medicinal agent in blocking or slowing oxidative stress related degenerative diseases. Argemone mexicana have been reported for in vitro oxidant activity. The present study aimed to evaluate cardioprotective potential screened in Doxorubicin induced cardiac stress in which Ethanolic Extract of Argemone Mexicana Leaves(EAML 200 mg/kg,400mg/kg) were administered to both Doxorubicin(15mg/kg i.p.) administered groups respectively. The present study concludes that restoration of Haemodynamic Parameters(BP,ECG),Biochemical parametsrs-cardiac markers(CK-MB,LDH,SGOT), antioxidant markers(MDA,CAT,SOD,GTH)) Histopahological indications. Keywords: Doxorubicin, Antioxidant, ECG, Blood pressure, Cardiotoxicity