A spasm is a sudden, involuntary contraction of a muscle, group of muscles, or hollow organ, such as the bladder. Spasms can be brief but severe and painful. Muscle spasms occur when your muscle involuntarily and forcibly contracts uncontrollably and can’t relax. Muscle spasms are normal and quite common. Spasmolytic drugs are also known as antispasmodic drugs or centrally acting muscle relaxant. A spasmolytic agent is a type of medication that reduces excessive smooth muscle contraction in body, commonly used to alleviate symptoms like abdominal cramps and pain associated with conditions such as irritable bowel syndrome. It is associated with cerebral palsy, multiple sclerosis, stroke. The generation of neuronal signals in motor neurons that cause muscle contraction depend on balance of synaptic excitation and inhibition of motor neuron receives.