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image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao ZENODOarrow_drop_down
image/svg+xml Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao Closed Access logo, derived from PLoS Open Access logo. This version with transparent background. http://commons.wikimedia.org/wiki/File:Closed_Access_logo_transparent.svg Jakob Voss, based on art designer at PLoS, modified by Wikipedia users Nina and Beao
ZENODO
Doctoral thesis . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Thesis . 2024
License: CC BY
Data sources: Datacite
ZENODO
Thesis . 2024
License: CC BY
Data sources: Datacite
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3D BIOPRINTING OF ARTIFICIAL MENISCUS WITH TUNABLE MECHANICAL PROPERTIES

Authors: Pashpuleti, Rahul;

3D BIOPRINTING OF ARTIFICIAL MENISCUS WITH TUNABLE MECHANICAL PROPERTIES

Abstract

Meniscal injuries are prevalent in orthopedics, often leading to compromised knee function and increased osteoarthritis risk. This study develops a hybrid bioink for 3D bioprinting artificial menisci with tunable mechanical properties, addressing the limitations of traditional repair methods. Through rheological analysis, tensile, and compression testing, the research identifies an optimal bioink composition of 50% polycaprolactone (PCL), 10% gelatin methacrylate (GelMA), and 7% sodium alginate (SA). This formulation achieves a favorable balance of mechanical strength and swelling behavior, closely mimicking the native meniscus. Specifically, the bioink provides sufficient stiffness to support structural integrity and elasticity to absorb impact, while also maintaining superior swelling properties to simulate the hydration and load-bearing characteristics of natural meniscus tissue. The findings highlight the potential of 3D bioprinted menisci in orthopedic applications, offering a promising approach for personalized meniscus repair and advancing regenerative medicine.

Keywords

3D bioprinting, tunable properties, artificial meniscus

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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