Objectives: To compare the effectiveness of CBT and RT on fatigue among teaching professionals with CFS. Method: Quasi experimental with time series design was adopted. The study was conducted at selected schools in chennai. 30 samples who fulfilled the inclusive criteria were included in this study using non probability convenient sampling technique. Fatigue severity scale was used for data collection.Results: The mean difference score of fatigue had significant values, showed the effectiveness of cognitive behavioral therapy and relaxation therapy. The reliability of the tool was measured by test and retest method. Conclusion: the pilot study revealed the data collection tools were reliable and practicable to carry out the main study. There is significant improvement in fatigue in both CBT group and RT group when compared with control group.When compared to RT, CBT shows better improvement in fatigue.