We used phylogenomics to investigate patterns of gene family evolution across ticks and other chelicerates, which include a diverse array of parasites. We used phylogenetic profiling and trait-association tests to predict gene families that may enable parasitic species to feed on hosts undetected for prolonged periods (>1 day). This release accompanies the pub, “Comparative phylogenomic analysis of Chelicerates points to gene families associated with long-term suppression of host detection." Please see the pub for more information. chelicerata-v1-10062023.zip contains the outputs from NovelTree that are needed as inputs for phylogenetic profiling. annotated.zip contains gene annotations used to do orthogroup filtering. tx2gene.tsv has presence/absence of expression for each Amblyomma americanum transcript. chelicerate_proteome_preprocessing_outputs.zip contains the outputs of chelicerate protein data curation. chelicerata-v1-parameterfile.json & chelicerata-v1-samplesheet.csv were inputs for setting up the initial NovelTree run. 2024-06-24-all-chelicerate-noveltree-proteins.fasta has the full set of chelicerate protein sequences. summary_of_noveltree_results.zip contains summary figures from the outputs of the NovelTree run. chelicerate-samples.tsv is the sample sheet used in proteome curation upstream of NovelTree.