Oral disintegrating films (ODFs) are innovative drug delivery systems designed to dissolve rapidly in the oral cavity without the need for water. These films are particularly beneficial for patients who have difficulty swallowing traditional dosage forms, such as the elderly and paediatric populations. This study aims to develop ODF containing Brivaracetam were formulated using a different grade of HPMC E15 and HPMC E50 and plasticizers like polyethylene glycol and propylene glycol using solvent casting method. The formulated films were evaluated for thickness, folding endurance, weight variation, percentage elongation, drug content, in-vitro dissolution and in-vitro disintegration. The optimized formulation F4 containing HPMC E15 showed minimum disintegration time at 20 secs and highest in-vitro dissolution 98.9% within 10 mins. Stability data indicated no significant changes in parameters over time. Therefore, Formulation F4 is recognized as stable and effective. Hence oral disintegrating films represent a promising advancement in pharmaceutical formulations, offering a convenient and effective means of drug delivery. Their rapid dissolution and ease of use make them an attractive option for improving patient adherence to medication regimens.