Objectives: To evaluate the role of pharmacists in improving medication safety in cancer patients, examining the effectiveness of interventions led by pharmacists and their impact on patient outcomes. Methods: To locate research that met the inclusion criteria, a thorough computerized search of relevant databases was carried out. A comprehensive search was carried out on PubMed, SCOPUS, Science Direct, Cochrane Library, and Web of Science to locate relevant material. Results: The dataset comprised seven studies involving 11,329 cancer patients, with 4332 (38.2%) being male. Pharmacist involvement in oncology care, particularly in medication management, significantly enhances patient safety and treatment outcomes. Strategies like medication charting, opioid management, and chemotherapy verification prevent errors and improve well-being. Older cancer patients especially benefit from pharmaceutical care, with interventions identifying and addressing drug-related problems (DRPs). Collaboration between pharmacists, oncologists, and interdisciplinary teams optimizes medication use, ensures compliance, and reduces treatment risks across both inpatient and outpatient settings. Conclusion: The role of pharmacists in improving drug safety and treatment outcomes in oncology care is undeniable. Their interventions, particularly in managing complex regimens and addressing DRPs, have proven to be crucial for patient well-being. Strengthening collaboration between pharmacists and other healthcare providers can further enhance patient outcomes, especially for vulnerable populations such as the elderly. As the healthcare landscape continues to evolve, the role of pharmacists should be expanded and standardized to maximize their positive impact on patient care. Keywords: Pharmacists; Medication Safety; Medication errors; Adverse Drug Reactions; Pharmacological Interventions; Systematic review.