Climate change is leading to more extreme temperatures and precipitation. These changes promote the spread of certain waterborne diseases which are impacted by extreme temperatures, contamination of waterbodies through runoff, dry conditions, water scarcity, and poor sanitation. Diarrheal disease is one of the most prevalent waterborne diseases and is highly impacted by these climatic conditions. Diarrheal disease is a public health concern particularly among young children and in Sub-Saharan Africa. This topic area aims to quantify the health impacts of diarrheal disease attributable to extreme temperatures and precipitation. This is the Topic Introduction document.