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Many neurobiological abnormalities have been reported in patients with violent and criminal behaviour. Strong associations exist between aggressive/violent behaviour and brain dysfunction. Also, many studies support an association between frontal lobe dysfunction and increased aggressive or antisocial behaviour. The focal orbitofrontal brain injury is specifically associated with increased aggression. Deficits in frontal lobe executive functions may increase the likelihood of future aggression, but as of now, studies have reliably demonstrated a characteristic pattern of frontal network dysfunction predictive of violent crime. The evidence is strongest for an association between focal prefrontal damage and an impulsive subtype of aggressive behaviour. This paper covers dysfunctions in these regions contributing to severe aggressive and violent behaviour, as well as neurotransmitters implicated in the same.