This webinar, presented by the NIH Generalist Repository Ecosystem Initiative (GREI), provided an overview of the GREI repositories and guidance on best practices for sharing and discovering data in them. Generalist repositories offer researchers a flexible, trusted resource to share data for which there is no appropriate discipline specific repository as well as to share many other research outputs valuable for reproducibility and open science. This webinar, presented by repositories participating in the NIH Generalist Repository Ecosystem Initiative (GREI) (Dataverse, Dryad, Figshare, Mendeley Data, Open Science Framework, Vivli, and Zenodo) described generalist repository use cases, how generalist repositories fit into the NIH data repository landscape, and how they help meet NIH data management and sharing requirements. In it, we presented both the key common features of generalist repositories as well as the unique features of these repositories that make them suited to specific types of data. We also provided guidance on best practices for depositing and finding data in these repositories including how to make your research more discoverable and reusable and reinforce these best practices by sharing real world examples of NIH-funded research published in the GREI repositories. Key takeaways Overview of common & unique features of generalist repositories Discussion of when to share data in generalist repositories Guidance on generalist repository data sharing & discovery best practices Review of real world examples of NIH-funded research shared in generalist repositories Webinar recording