The deliverable D4.2 focuses on creating and managing Standard Operating Procedures (SOPs) for the Genomic Data Infrastructure (GDI) network to ensure standardised practices across diverse nodes. Its main objectives include developing a framework for SOP management, creating both European-level and Node-specific SOPs, and establishing a system for SOP request, development, review, approval and authorization. Key achievements include: Formation of a task group involving representatives from nine GDI nodes to guide SOP development. Across 2024, these nodes covered both onboarding and deployment stages. Creation of a flexible SOP framework, supporting both common and node-specific needs. Establishment of a GitHub-based platform for SOP management, with automated workflows. Completion of three SOPs, with several others in development. While progress has been made, some delays occurred due to the absence of key committees required for formal SOP approval. Looking forward, efforts will focus on expanding the SOP library, transitioning to a GDI-managed platform, aligning SOPs with standards and developing a monitoring framework for nodes, including self-assessments.