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PanTheraDB

Authors: A. Campana, Pedro; Herwig, Ralf; Prasse, Paul; Scheffer, Tobias;
Abstract

This database contains the predictions of synergy scores between triplets of more than 100 drugs treating the cell-lines from the NCI60. Columns: NSC1: The NSC of the first drug found in the tripletNSC2: The NSC of the second drug found in the tripletNSC3: The NSC of the third drug found in the tripletCELL_NAME: The name of the treated cell-lineBliss: The synergy score (ComboScore_{1 /to 3} defined by MEAN(PREDICTED - EXPECTED_BLISS) using the best performing model. Where EXPECTED_BLISS uses the multiplicative survival principle based on the individual dose-responses against each drug in the triplet and MEAN represents the average over the different combinations of concentrations.Multi: The synergy score (ComboScore_{2 /to 3} defined by MEAN(PREDICTED - EXPECTED_MULTI) using the best performing model. Where EXPECTED_MULTI is defined as the minimum over the three possible pair-single drug combinations in the triplet, using the multiplicative survival principle.{synergy}_q{XX}: Quantile XX for the synergy aggregated over an ensemble containing 10 models

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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average