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ZENODO
Preprint . 2024
License: CC BY
Data sources: ZENODO
ZENODO
Preprint . 2024
License: CC BY
Data sources: Datacite
ZENODO
Preprint . 2024
License: CC BY
Data sources: Datacite
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Claim

Trastuzumab resistance features GRK2 activation.

descriptionPublicationkeyboard_double_arrow_right Preprint 27 Oct 2024Publisher:Zenodo
Authors: Mamoor, Shahan;

doi: 10.5281/zenodo.13997162 , 10.5281/zenodo.13997161

Trastuzumab resistance features GRK2 activation.

Abstract

We studied whole tumor gene expression in humans with pathologic complete response (pCR) or residual disease (RD) following treatment for HER2+ breast cancer to discover gene expression changes associated with, resulting from or causing resistance to treatment with the HER2-targeted treatment trastuzumab (Herceptin). We identified activation of GRK2 in humans whose tumors display resistance to treatment with trastuzumab. Studying whole transcription in HER2+ breast cancer cells engineered to develop trastuzumab-resistance in vitro validated this phenomena. GRK2 activation likely supports resistance to trastuzumab in humans with HER2+ breast cancer. 

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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Related to Research communities
Cancer Research