This data set reports on data recorded during four measurement campaigns in the lower segment of the River Noce, Italy.The measurements were aimed at characterising CO2 fluxes along the river, and were conducted using a combination of loggers (time-resolved data) and sampling (space-resolved data).The data were collected in the Santa Giustina reservoir (upstream reservoir), along the residual flow reaches that extend between the Santa Giustina reservoir and the outlet of the hydropower diversion system in Mezzocorona, and downstream of the diversion outlet. The data is provided as Matlab .mat files.For more information about the data set and data acquisition, please contact the author or refer to the following article: Dolcetti, G., Piccolroaz, S., Bruno, M. C., Calamita, E., Larsen, S., Zolezzi, G. & Siviglia, A. Quantification of carbopeaking and CO2 fluxes in a regulated Alpine river.