World Health Organisation (WHO) report stated that “Tobacco is the single most preventable cause of death in the world today. By 2030, the death toll will exceed eight million a year” (WHO, 2008). The carcinogens in tobacco can directly alter the genetic code, or their constituent metabolites can affect various pathways and genes (Anand, 2008). Our aim is to identify tobacco-derived metabolites, that are consumed during smoking and by the use of smokeless tobacco, that are playing a major role in the initiation and progression of various cancer types to provide a novel insight into tobacco mediated cancer.