SEISMEC aims to demonstrate the concept of human-centricity across a wide array of industry sectors, scales and sociotechnical contexts in the EU. Through 17 pilots spanning 14 key industrial ecosystems embedded in the European Single Market, SEISMEC will demonstrate how human-centric solutions can effectively empower workers in the co-design and co-development of new technologies, thus facilitating the journey towards a skills-driven and creativity-infused industrial landscape; one that is built around high-quality, sustainable jobs, and prioritises overall worker security and satisfaction. SEISMEC advocates for a multidimensional transformation that hinges on fair and trustworthy technology, ethical incentives, capacity building and democratisation as key enablers to fundamentally change the way workers see themselves and are seen within their organisations.