This article presents a comparative linguistic analysis of polygraphic units in English and Uzbek languages. It explores the structural and semantic characteristics of polygraphic elements, examining their similarities and differences in both languages. The study highlights how these polygraphic units, including abbreviations, acronyms, and initialisms, function within their respective linguistic systems. The research provides insights into the historical and cultural factors influencing the development and use of these units. By comparing English and Uzbek polygraphic units, this work contributes to the understanding of how polygraphy evolves across different language systems and enriches modern lexicology.