In this policy brief, we highlight the critical role of headline indicators in monitoring progress towards the goals of the Kunming-Montreal Global Biodiversity Framework (GBF). We argue that to enhance the effectiveness of these and other indicators, we need to implement FAIR principles (Findability, Accessibility, Interoperability, and Reusability) across all components involved in indicator calculation—data, workflows, and indicators themselves. Key points include: FAIR Principles: The necessity for all data and methodologies to be openly shared and adhere to FAIR principles to facilitate collaborative monitoring efforts among Parties to the Convention on Biological Diversity (CBD). Standardized Metadata: The importance of guidelines and standardized metadata to ensure consistent usage and interpretation of indicators, with new indicators developed following established standards. Support for Capacity Building: Continuous support is essential for building capacity and developing user-friendly tools to promote broader adoption of indicators across various countries. Implementation Infrastructure: A robust and interconnected data and informatics infrastructure is required to streamline the collection, harmonization, and sharing of biodiversity data and workflows. Policy Recommendations: We call for increased support for data repositories, the development of interconnected infrastructures, adherence to Open and FAIR principles, and the standardization of metadata to improve the usability of indicators. In conclusion, we advocate for a comprehensive and collaborative approach to biodiversity monitoring, emphasizing the need for standardization, transparency, and sustained support to effectively track and report on biodiversity changes globally. Funded by the European Union. B3 (Biodiversity Building Blocks for policy) receives funding from the European Union’s Horizon Europe Research and Innovation Programme (ID No 101059592).