Background: Intraoperative hemodynamic changes, post-operative nausea and vomiting (PONV), and post-operative pain are common challenges in middle ear surgeries. This study compared the effects of oral clonidine and gabapentin as premedication on these parameters. Objectives: The study aimed to evaluate and compare the effects of a single dose of oral clonidine (150mcg) and oral gabapentin (300mg) on intraoperative hemodynamics, PONV incidence, post-operative pain relief, and adverse effects in patients undergoing middle ear surgeries. Methods: A prospective, randomized, double-blind study was conducted on 180 ASA I and II patients divided into three groups (n=60 each): clonidine, gabapentin, and placebo. The study drugs were administered one hour before surgery. Intraoperative hemodynamics, PONV incidence, post-operative pain scores (VAS), and adverse effects were recorded. Results: Clonidine and gabapentin significantly reduced heart rate and blood pressure compared to the placebo group (p<0.05). PONV incidence was significantly lower in the clonidine and gabapentin groups (p<0.05), with clonidine showing better results. Post-operative VAS scores were significantly lower in the clonidine and gabapentin groups (p<0.05), with clonidine providing better pain relief. No significant adverse effects were noted. Conclusions: Premedication with oral clonidine (150mcg) or gabapentin (300mg) effectively attenuates intraoperative hemodynamic changes, reduces PONV incidence, and provides better post-operative pain relief compared to placebo in patients undergoing middle ear surgeries. Clonidine showed superior results compared to gabapentin.

Background: Intraoperative hemodynamic changes, post-operative nausea and vomiting (PONV), and post-operative pain are common challenges in middle ear surgeries. This study compared the effects of oral clonidine and gabapentin as premedication on these parameters. Objectives: The study aimed to evaluate and compare the effects of a single dose of oral clonidine (150mcg) and oral gabapentin (300mg) on intraoperative hemodynamics, PONV incidence, post-operative pain relief, and adverse effects in patients undergoing middle ear surgeries. Methods: A prospective, randomized, double-blind study was conducted on 180 ASA I and II patients divided into three groups (n=60 each): clonidine, gabapentin, and placebo. The study drugs were administered one hour before surgery. Intraoperative hemodynamics, PONV incidence, post-operative pain scores (VAS), and adverse effects were recorded. Results: Clonidine and gabapentin significantly reduced heart rate and blood pressure compared to the placebo group (p<0.05). PONV incidence was significantly lower in the clonidine and gabapentin groups (p<0.05), with clonidine showing better results. Post-operative VAS scores were significantly lower in the clonidine and gabapentin groups (p<0.05), with clonidine providing better pain relief. No significant adverse effects were noted. Conclusions: Premedication with oral clonidine (150mcg) or gabapentin (300mg) effectively attenuates intraoperative hemodynamic changes, reduces PONV incidence, and provides better post-operative pain relief compared to placebo in patients undergoing middle ear surgeries. Clonidine showed superior results compared to gabapentin.