Aim: Effect of single dose dexmedetomidine given prior to extubation-on-extubation conditions in adult patients following general anaesthesia. Material and methods: This prospective, randomized, study was carried out in the Department of Anaesthesia and Critical Care, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India for 15 months. After obtaining informed written consent for participation in the study, 50 adult patients aged 18-70 years belonging to American Society of Anaesthesiologists physical status (ASA PS) class I-II of both genders undergoing elective surgeries were enrolled. Results: Incidence of cough at extubation was comparable in both groups (68% vs. 66%, p 1.11). Baseline mean arterial pressure was comparable in both groups, but at 3min after extubation it was significantly lower in Group A. Heart rate, postoperative nausea, vomiting, shivering and sedation scores did not show any significant difference between the two groups (p>0.05). Conclusion: An infusion of dexmedetomidine at 0.75mcg/kg prior to extubation did not affect the severity of cough but resulted in improved hemodynamics at predefined time points after extubation.

Aim: Effect of single dose dexmedetomidine given prior to extubation-on-extubation conditions in adult patients following general anaesthesia. Material and methods: This prospective, randomized, study was carried out in the Department of Anaesthesia and Critical Care, Anugrah Narayan Magadh Medical College and Hospital, Gaya, Bihar, India for 15 months. After obtaining informed written consent for participation in the study, 50 adult patients aged 18-70 years belonging to American Society of Anaesthesiologists physical status (ASA PS) class I-II of both genders undergoing elective surgeries were enrolled. Results: Incidence of cough at extubation was comparable in both groups (68% vs. 66%, p 1.11). Baseline mean arterial pressure was comparable in both groups, but at 3min after extubation it was significantly lower in Group A. Heart rate, postoperative nausea, vomiting, shivering and sedation scores did not show any significant difference between the two groups (p>0.05). Conclusion: An infusion of dexmedetomidine at 0.75mcg/kg prior to extubation did not affect the severity of cough but resulted in improved hemodynamics at predefined time points after extubation.