This data was generated as part of the Tumor Profiler study. If you use it in your research, please cite: Wegmann, R., Bonilla, X., Casanova, R. et al. Single-cell landscape of innate and acquired drug resistance in acute myeloid leukemia. Nat Commun 15, 9402 (2024). https://doi.org/10.1038/s41467-024-53535-4 Derived data - scRNA-seq This is an R data set (.RDS) containing a SingleCellExperiment object with the following slots: Assays: counts: raw counts colData: Cell-level metadata barcodes: The cell barcode fractionMT: Fraction mitochondrial genes per cell n_umi: Total number of UMIs per cell n_gene: Total number of genes per cell log_umi: log10 total number of UMIs per cell g2m_score: Cell cycle phase score for G2M s_score: Cell cycle phase score for S cycle_phase: predicted cell cycle phase celltype_major_full_ct_name: Major cell type full name celltype_major: Major cell type short name celltype_final_full_ct_name: Cell subtype full name celltype_final: Cell subtype short name sample_id rowData: Gene-level metadata gene_ids gene_names Derived data - CyTOF This is an R data set (.RDS) containing a SingleCellExperiment object with the following slots: Assays: counts_raw: signal intensity based on CyTOF dual counts exprs_raw: arcsinh transformed raw counts (cofactor 5) counts: batch corrected raw counts (linear scaling based on a quantile) exprs: arcsin transformed counts (cofactor 5) scaled: 0-1 normalized exprs (clipped to the 99.95th percentile) colData (cell metadata) bc_id: barcode of the sample during staining run: CyTOF experiment batch, named after the first sample of the batch type: Sample type (blood or bone marrow) sample_id: TuPro sample ID pred_id: Predicted cell type [char] pred_n: Predicted cell type [integer] rowData (marker metadata) channel_name: Name and isotopic mass of the metal ion corresponding to this marker marker_name: Protein name channel_group, channel_group_integer: Biological processes the channel identifies, e.g. specific cell type, signalling, cell death tsne_channel: Logical - use this channel for dimensionality reduction? channel_order: Define the order of channels for plotting cluster_channel: Logical - use this channel for clustering?