This repository contains the immunoSEQ T-cell receptor (TCR) and B-cell receptor (BCR) repertoire data used in the manuscript titled "Adaptive immune responses to Omicron BA.4/BA.5-containing bivalent mRNA booster vaccination". This data set is composed of the TCR/BCR repertoire clonotype sequences and abundances derived from human peripheral blood mononuclear cell (PBMC) samples sorted for CD4, CD8 and CD19 before and after bivalent COVID mRNA booster vaccination. In total, 84 TCR samples (CD4+/CD8+ T cell populations at pre-/post-vaccination from 21 subjects) and 42 BCR samples (CD19+ populations at at pre-/post-vaccination from 21 subjects) are present in the data set. Delmonte_TCR_data_84samples.rdsR object with the amino acid and nucleotide sequences, VDJ gene calls, and abundances of the TCR clonotypes. Delmonte_BCR_data_42samples.rds R object with the amino acid and nucleotide sequences, VDJ gene calls, and abundances of the BCR clonotypes. Delmonte_TCR_data_compact_84samples.rdsR object with the amino acid sequences, VDJ gene calls, and abundances of the TCR clonotypes. Delmonte_BCR_data_compact_42samples.rds R object with the amino acid sequences, VDJ gene calls, and abundances of the BCR clonotypes. sampleExport_TCR.zipCompressed folder that includes the individual sample level TCR repertoire files in .tsv format. sampleExport_BCR.zipCompressed folder that includes the individual sample level BCR repertoire files in .tsv format. Funding statement: This work was supported by the Division of Intramural Research Programs of the National Institute of Allergy and Infectious Diseases and of the National Institute of Dental and Craniofacial Research, National Institutes of Health (grant AI001270).