Plastics are a source of pollution throughout their entire life cycle from extraction, involving releases of greenhouse gases (GHGs), micro- and nanoplastic (MNPs) contamination, and hazardous chemicals such as endocrine disruptors, causing exposure to humans and the environment. This policy brief focuses on plastic chemicals of concern, which spans from extraction of feedstocks, through conversions to monomers, polymerization, formulation, and molding, use, management, and removal and remediation. Plastics can deposit chemical contaminants over time into everything, such as food, water, soil, clothing, air and living organisms, including humans.