ABSTRACT Nasal drug delivery holds promise for improved bioavailability, offering rapid onset of action and bypassing first-pass metabolism. This article explores advanced strategies to optimize drug absorption via the nasal route. It discusses the utilization of technology for precise drug targeting and enhanced permeation across mucosal barriers. Additionally, it examines the role of polymers in prolonging residence time and promoting sustained drug release. Permeation enhancers and microemulsions are explored for their potential to overcome biological obstacles and enhance drug absorption. Moreover, advancements in nasal delivery device design are highlighted for their pivotal role in ensuring accurate dosing and patient compliance. By synthesizing these strategies, the article aims to guide researchers and pharmaceutical developers towards the creation of more effective nasal drug delivery systems with enhanced bioavailability and therapeutic outcomes. Keywords: Nasal vaccines, Bio adhesive polymers