Abstract The present research studied the relationship between Triguna personality and psychological well-being. Psychological well-being helps in all domains of an individual.A sample of one hundred thirty women participants with ages ranging from 18 years to 64 years wasdrawn to fill the Vedic Personality Inventory and Psychological Well-Being Scale. Measures of psychological well-being are characterized in terms of environmental mastery, autonomy, positive relations, and purpose in life, personal growth, and self-acceptance. Indian Vedic philosophy suggests about Triguna personality which consists of Sattvic, Rajsic, and Tamasic qualities. Coefficients of correlation revealeda significant positive association of Sattvic and negative of Rajsic and Tamsic with all measures of psychological well-being.It depicted that an individual characterized as high on Sattva guna tends to be high on psychological well-being whereas persons high on Rajas and Tamas will be low on psychological well-being.Factor analysis suggested the extraction of two factors using by the criterion of eigenvalue greater than 1.00. Extracted factors supported the results of the correlational analysis.Stepwise multiple regression analysis depicted thatoverall psychological well-being (composite score)was significantly predicted by Tamsic (R2=.432; ?=-0.658),Sattvic (R2=.524; ?=0.567) and Rajsic(R2=.541; ?=-0.189). In conclusion, Triguna personality influences the Psychological Well-Being of an individual.