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Report . 2024
License: CC BY
Data sources: Datacite
ZENODO
Report . 2024
License: CC BY
Data sources: Datacite
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PREPARATION AND OPTIMIZATION OF DEFERASIROX IMMEDIATE RELEASE TABLETS

Authors: Mohd Ismail Khalid Hashmi*, Dr.Y.Ganesh Kumar;

PREPARATION AND OPTIMIZATION OF DEFERASIROX IMMEDIATE RELEASE TABLETS

Abstract

The objective of this study is to formulate and significantly improve the bioavailability and reduce the side effects of immediate release tablets of Deferasirox. The precompression blends of Deferasirox were characterized with respect to angle of repose, bulk density, tapped density, Carr’s index and Hausner’s ratio. The precompression blend of all the batches indicates well to fair flowability and compressibility. Immediate release tablets were prepared with various polymers like Croscarmellose sodium, Sodium starch glycolate and Crospovidone at different concentration ratios and were compressed into tablets. The formulated tablets were evaluated for various quality control parameters. The tablets were passed all tests. Among all the formulations F7 formulation containing, drug and Sodium starch glycolate showed good result that is 99.94 % in 45 min. Hence from the dissolution data it was evident that F7 formulation is the better formulation. Keywords: Deferasirox, Immediate release, Croscarmellose sodium, Sodium starch glycolate, Crospovidone.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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