Background: Non-tuberculous mycobacteria (NTM) lung infections are complex and challenging to manage, requiring a multidisciplinary approach. Respiratory therapists (RTs) play a critical role in managing these infections through airway clearance, supporting antibiotic therapy adherence, and providing patient education.Objective: This study explores the collaborative role of respiratory therapists in the management of NTM lung infections, focusing on their contributions to airway clearance, medication adherence, and patient education within a multidisciplinary team.Methods: A qualitative descriptive study was conducted in a large tertiary care hospital, involving semi-structured interviews and focus group discussions with 25 healthcare professionals, including 15 respiratory therapists. Thematic analysis was used to identify key themes related to the role of RTs in NTM management.Results: The findings revealed that RTs are integral to the management of NTM lung infections, providing expertise in personalized airway clearance techniques, educating patients on complex antibiotic regimens, and fostering patient self-management. Effective multidisciplinary collaboration was highlighted as crucial for optimizing patient outcomes.Conclusion: Respiratory therapists play a vital role in managing NTM lung infections within a multidisciplinary framework. Enhancing training, standardizing protocols, and strengthening team collaboration are essential for improving patient care.