This dataset encompasses a detailed collection of clinical trial protocols focused on the management of Intervertebral Disc Degeneration (IVD) from January 2013 to September 2024. It includes a diverse range of interventions, highlighting device, drug, and biological treatments, and documents the evolving strategies in response to the shifting landscape of pain management, particularly in the post-opioid epidemic era. The protocols have been rigorously compiled to identify trends, assess the effectiveness of various treatment modalities, and pinpoint knowledge gaps in the current research. By providing standardized data, this dataset serves as a valuable resource for researchers and clinicians aiming to enhance therapeutic approaches and outcomes for IVD patients worldwide. The inclusion of multiple intervention types and the comprehensive nature of the data make this collection a pivotal tool for advancing research and improving patient care in the field of spinal health.