The article discusses the hormonal aspects of acne vulgaris pathogenesis in adolescents and adults. Particular attention is paid to the influence of sex hormones, such as androgens and progesterone, on the development and course of the disease. The clinical features of acne associated with hormonal changes, as well as various therapeutic approaches, including the use of topical and systemic drugs, hormonal contraceptives and antiandrogens are considered. Emphasis is placed on the need for an integrated approach to treatment, including control of stress factors.