Indapamide is a Thiazide- suchlike diuretic medicine used in the treatment of hypertension Since 1977. Class of Thiazide- Suchlike diuretics. It shows great capability to overcome Hypertension as well as Heart failure. Different analytical method used to get to determine a chemical or physical property of a chemical substance, chemical element, or mixture. Even though Indapamide has had the approval for clinical use for more than 30 years now most of the analytical methods for its determination reported in the scientific literature are the ones which utilize different analytical methods. This shows which method and which Solvents are more efficient to determine Indapamide.