Common issues with traditional dosing forms, such as pills and capsules, include dysphagia, which increases the likelihood of noncompliance and renders the treatment ineffective. Mouth dissolving tablets, which have good hardness, dose homogeneity, and ease of administration, have been designed to eliminate the issues with conventional dosage forms. They are the dosage form of choice for pediatric, geriatric, and travel patients. Researchers seeking methods to improve patients' adherence to their prescribed medications have long been interested in developing more complex oral medication delivery systems. By eliminating administration problems and extending the patent life, mouth-dispensing drug delivery systems (MDDDS) have become a dominant player in the industry. There is no requirement for water during administration of MDDDS because they dissolve and release the drug immediately when they meet saliva. Consequently, these dosage forms have attracted a certain demographic of patients, including those with swallowing difficulties, those who are bedridden, those with mental health issues, the elderly, and children. To improve the disintegration quality of these delicate dosage forms without sacrificing their integrity, several new approaches have been developed recently. Considering the unique characteristics of these dosage forms, this paper seeks to give a comprehensive review of the technical progress achieved so far in the evaluation of mouth-dissolving tablets.