Background: The most common causes of peptic ulcer disease (PUD) are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the PUD leads to perforation. Perforation of gastric or duodenal ulcer is one of the most serious and overwhelming catastrophes that can befall on human being. The incidence of peptic ulcer disease has decline in worldwide in recent years following judicious use of wide spectrum and highly effective ulcer healing drugs. Despite the widespread use of gastric antisecretory agents and H. pylori eradication therapy the incidence of perforated peptic ulcer has changed little. Aim: The current study aims to check the involvement of the H. pylori in peptic perforations and whether by eradicating the bacterium H. pylori can we prevent the ulcer recurrence in post operative peptic perforation patients. Materials and Methods: After the confirmation of peptic perforation and detecting the H. pylori infection patients were subjected to graham’s repair by both open and laparoscopic method. Then after recovery they were included in the trial category. This study also involves the comparison between effectiveness of triple therapy regimen over esomeprazole alone therapy in post-operative periods. The patients were advised to follow up upto 1 year and ulcer recurrence was observed. Results: Study was conducted on 128 patients, out of which 68 were excluded and remaining 60 patients were included in the study. 30 patients were included in triple therapy group and 30 to only esomeprazole therapy group. After 1 yr. follow up it was found that 25(83.3%) out of 30 patients and 5(16.6%) out of 30 patients has H. pylori eradication. Ulcer recurrence occurred 3.3% in case triple therapy and 36.6% in case of only esomeprazole therapy. Conclusions: In this study it was found that in cases of peptic perforations triple therapy (anti- helicobacter pylori therapy) is superior to esomeprazole alone in the eradication of H. pylori. Triple therapy also prevents long term recurrence of ulcer in post operative peptic perforation in 1 year follow up study.

Background: The most common causes of peptic ulcer disease (PUD) are Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs), and the PUD leads to perforation. Perforation of gastric or duodenal ulcer is one of the most serious and overwhelming catastrophes that can befall on human being. The incidence of peptic ulcer disease has decline in worldwide in recent years following judicious use of wide spectrum and highly effective ulcer healing drugs. Despite the widespread use of gastric antisecretory agents and H. pylori eradication therapy the incidence of perforated peptic ulcer has changed little. Aim: The current study aims to check the involvement of the H. pylori in peptic perforations and whether by eradicating the bacterium H. pylori can we prevent the ulcer recurrence in post operative peptic perforation patients. Materials and Methods: After the confirmation of peptic perforation and detecting the H. pylori infection patients were subjected to graham’s repair by both open and laparoscopic method. Then after recovery they were included in the trial category. This study also involves the comparison between effectiveness of triple therapy regimen over esomeprazole alone therapy in post-operative periods. The patients were advised to follow up upto 1 year and ulcer recurrence was observed. Results: Study was conducted on 128 patients, out of which 68 were excluded and remaining 60 patients were included in the study. 30 patients were included in triple therapy group and 30 to only esomeprazole therapy group. After 1 yr. follow up it was found that 25(83.3%) out of 30 patients and 5(16.6%) out of 30 patients has H. pylori eradication. Ulcer recurrence occurred 3.3% in case triple therapy and 36.6% in case of only esomeprazole therapy. Conclusions: In this study it was found that in cases of peptic perforations triple therapy (anti- helicobacter pylori therapy) is superior to esomeprazole alone in the eradication of H. pylori. Triple therapy also prevents long term recurrence of ulcer in post operative peptic perforation in 1 year follow up study.