Abstract: Many attempts were undertaken to modify this drug at the phenyl ring, acetamido group, and hydroxyl group in an effort to boost its efficacy, hide its bitter taste, and lessen its toxicity after it proved effective in the market as an over-the-counter antipyretic and analgesic. Paracetamol uses a variety of methods to lower body temperature. Chemically speaking, paracetamol is 4-hydroxy acetanilide and has a solid safety record. Chemical reactions based on nanoparticles are beginning to take the place of bulk material-based reactions. Owing to its many benefits, including the capacity to easily introduce multifunctionality, increase chemical activities, photochemical stability, and the conversion of partials into nano dimension, In this work we propose Tetra-o-acetyl-B-D-glucosyl N-acetyl-4-hydroxyl acetanilide have been synthesized for the first time by the interaction of Tetra-O-benzoyl-B-D-glucosyl isothiocyanate and Paracetmol. All the synthesized compounds were characterized on the basis of elemental analysis and XRD studies. The polarimetric study of the title compounds has been carried out.