Abstract: In the present study the extract of Blumea species in ethanol was assessed by analysis with high resolution liquid chromatography mass spectrometry (HRLCMS/MS) it shows many bioactive compounds, this study highlights presence of Physalin G, Harderophyrin, Euphornin and many more compounds. Network pharmacology approach was used find out potential activities. SAR was performed by online tool PASS for screening of activity such as anticancer, antineoplastic or anti-inflammatory which can be used for analysis. By using different tools and software information related to potential activity was collected, various servers like RCSB-PDB, PubChem, protein plus server, PyMol, PyRx, Discovery studio visualiser, UCSF Chimera was used. In this study, EGFR was used as target with PDB ID (5xdk) with 8jc ligands and the binding affinity was for 5xdk target and ligands reported the highest binding affinity for 5xdk with 8JC -8.8, 5xdk with Euphornin -7.8, 5xdk with Harderoporphyrin -8.6 and 5xdk with Physalin g -8.8.