Introduction: Fentanyl synergistically enhances propofol effects and reduces hemodynamic response during induction. Fentanyl and propofol administration timing affects propofol dose and associated side effects. Aim and Objectives: Primary objective is to calculate the total dose of propofol required to achieve loss of consciousness during induction of anesthesia. Secondary objective is to examine the Incidence of hypotension during induction and to examine any Incidence of any movement or Bucking or Any vocalization after initial dose of propofol. Materials & Methods: After institutional ethical clearance, 68 ASA status I & II patients, aged 18-65 years, undergoing elective surgery under general anesthesia were randomized into two groups; Fentanyl 2 mcg/kg was administered immediately prior to, 5 and 7 min before induction with propofol in Groups A and B, respectively. The requirement of propofol induction dose and hemodynamic parameters was recorded. Statistical analysis was performed using software SPSS, P-value <0.05 was considered statistically significant. Results: Demographic characteristics were comparable in both the groups. Total dose of propofol required for induction was higher in Groups A than group B (Group A vs. 85.88±14.221mg vs. 56.52±12.530 mg). Incidence of movement, vocalization, bucking is higher in Group A than Group B (P=<0.000001, P=0.002, P=0.007 respectively). Incidence of hypotension during induction was significantly lower in Group B (5.9%) than Group A (94.1%; P =<0.00001). Conclusion: Administering fentanyl 7 min prior to propofol causes marked reduction in the dose requirement of the propofol along with a significantly decreased incidence of hypotension during induction.

Introduction: Fentanyl synergistically enhances propofol effects and reduces hemodynamic response during induction. Fentanyl and propofol administration timing affects propofol dose and associated side effects. Aim and Objectives: Primary objective is to calculate the total dose of propofol required to achieve loss of consciousness during induction of anesthesia. Secondary objective is to examine the Incidence of hypotension during induction and to examine any Incidence of any movement or Bucking or Any vocalization after initial dose of propofol. Materials & Methods: After institutional ethical clearance, 68 ASA status I & II patients, aged 18-65 years, undergoing elective surgery under general anesthesia were randomized into two groups; Fentanyl 2 mcg/kg was administered immediately prior to, 5 and 7 min before induction with propofol in Groups A and B, respectively. The requirement of propofol induction dose and hemodynamic parameters was recorded. Statistical analysis was performed using software SPSS, P-value <0.05 was considered statistically significant. Results: Demographic characteristics were comparable in both the groups. Total dose of propofol required for induction was higher in Groups A than group B (Group A vs. 85.88±14.221mg vs. 56.52±12.530 mg). Incidence of movement, vocalization, bucking is higher in Group A than Group B (P=<0.000001, P=0.002, P=0.007 respectively). Incidence of hypotension during induction was significantly lower in Group B (5.9%) than Group A (94.1%; P =<0.00001). Conclusion: Administering fentanyl 7 min prior to propofol causes marked reduction in the dose requirement of the propofol along with a significantly decreased incidence of hypotension during induction.