Systemic Lupus Erythematosus (SLE) is an autoimmune rheumatic disease that has variety symptoms and affects multi organ or system in the body. ACR criteria has made in 1997 for the diagnosis of SLE disease and in 2012 appeared a new criteria to diagnose SLE: SLICC criteria. The purpose of this study was to determine the diagnostic criteria SLICC compared to the ACR criteria in diagnosing patients with SLE in Haji Adam Malik Hospital in 2010-2017. Method: This research is an analytic cross-sectional study type. The data collection was conducted by using the medical records of patients with SLE at Adam Malik Hospital in 2010-2017. Result:The results showed that SLE is most common in women, as many as 69 patients (89.6%) and majority in reproductive age (15-40 years) 65 patients (84.4%). Clinical manifestations that most of patients have consecutively are arthritis that as many as 75 patients (97.4%), immunological disorders as many as 61 patients (79.2%), and malar rash as many as 59 people (76.6%). The diagnostic value sensitivity SLICC criteria amounted to 88.7% and the specificity SLICC is at 100%. Conclusion: SLICC criteria diagnostic value compared to the ACR criteria is a sensitivity of 88.7% and specificity of 100%.