interTwin co-designs and implements the prototype of an interdisciplinary Digital Twin Engine (DTE). The developed DTE will be an open source platform that includes software components for modelling and simulation to integrate application-specific Digital Twins. InterTwin WP7 provides the aforementioned sets of software components, called thematic modules, for the use cases defined in WP4.The current document consists of an update of the D7.2 deliverable, containing a high-level description of the physics domain use cases and of the related designed thematic modules, specifying their stage of development. This deliverable also includes a description of the data and computing requirements of the thematic modules, which will need to be available in the DTE infrastructure designed in WP5 and in the core modules developed in WP6.