Background: 90-95% improvement which happens frequently and common cases is type 2 diabetes mellitus caused with increased blood glucose through degradation of insulin release by the pancreatic gland. Quality of sufferers life with type 2 diabetes mellitus isn’t decided by general health but also by dental and oral health. Purpose: To determine quality of life and oral hygiene conditions in sufferers against type 2 diabetes mellitus. Methods: This ​research using literature study from several research journal databases published in 2015-2023. Literature search use a strategy with criteria of type 2 diabetes mellitus, oral hygiene, and quality of life utilize Pubmed, Google Scholar, Science Direct, and Elsevier databases with article title criteria discuss the relationship between influences quality of life and oral hygiene in sufferers against type 2 diabetes mellitus. Results: There are respondents who have minimal knowledge about type 2 diabetes mellitus associated with dental and oral health in several studies. Majority of the female sufferers through type 2 diabetes mellitus. This disease related to the oral cavity causes pain and physical discomfort has negative effects on quality of life. Bacteria increase in the oral cavity and decrease saliva flow which causes xerostomia and decreases self-cleaning effect which can interfere with oral hygiene. Person with diabetes has higher effects of developing caries due to high levels of glucose in saliva. Conclusion: It's important for diabetes mellitus sufferers to always maintain their health status and oral hygiene.