Human Resource Management (HRM) is a science or method of managing the relationships and roles of resources (workforce) owned by individuals efficiently and effectively. HR management consists of HR planning, personnel selection, training and development, and performance assessment. The performance of nurses in hospitals is very important because it can influence performance in achieving health services in the hospital itself. This study aims to determine and analyze the influence of work experience and competency on the performance of nurses at RSD dr. Soebandi Jember. The data used in this research is primary data obtained through distributing questionnaires. The population in this study were all nurses at RSD dr. Soebandi, numbering 463 people. The sampling technique or method used was stratified random sampling, totaling 150 people. Validity and reliability analysis was carried out in this research. Hypothesis testing is also carried out for direct influence analysis. The research results stated that work experience had a significant effect on nurse performance. Nurse competency has a significant effect on nurse performance.