Dermatophytes, the fungi responsible for skin infections, have been increasingly exhibiting resistance to antifungal treatments, posing significant challenges to clinical management. This review explores the emerging issue of antifungal resistance in dermatophytosis, examining the mechanisms through which dermatophytes develop resistance and how these mechanisms impact treatment efficacy. The article delves into the various antifungal agents used in dermatophyte infections, their resistance profiles, and the implications for patient outcomes. Additionally, the review highlights recent advancements in diagnostic approaches and potential strategies to combat resistance. By synthesizing current research and clinical observations, this review aims to provide a comprehensive overview of antifungal resistance in dermatophytes and offer insights into future directions for improving treatment protocols.